Day 1
- Model building and diagnostics using NONMEM
7
..- Introduction
to NONMEM 7
..- Introduction
to diagnostics
..- Introduction
to PsN and Xpose
..- Residual
based diagnostics
..- Empirical
Bayes estimates based diagnostics
..- Shrinkage
& individual SEs
..- Hands-on
computer exercises with NONMEM 7, PsN and
Xpose
Day 2
- Advanced methods in NONMEM 7 and simulation
based diagnostics
..- Simulation
based diagnostics
..- Numerical
predictive checks
..- Mirror
plots and Visual Predictive checks
..- BLQ data
and simultaneous modeling of continuous
and categorical data
..- The bootstrap
and Case deletion diagnostics
..- Hands-on
computer exercises with NONMEM 7, PsN and
Xpose
Day 3
- Advanced methods in NONMEM 7 and computer
intensive model building and diagnostics
.. using NONMEM
7
..- Expectation
Maximization (EM) parameter estimation
..- Comparison
of methods
..- Prior functionality
in NONMEM 7
..- Bayesian
estimation
..- Nonparametric
estimation in NONMEM 7
..- Semi-parametric
distributions
..- Hands-on
computer exercises with NONMEM 7, PsN and
Xpose
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